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國際新聞精選周三(2017年2月22日)

Can Craig Venter Cheat Death?

THE WORLD’S MOST EXTREME physical exam starts in the world’s plushest exam room, complete with a couch, a private bathroom and a teeming fruit plate. It will be my home for an entire day. First come the blood tests, vial after vial. Then two 35-minute sessions in an MRI tube, where REM and U2 try to drown out the clanks as the machine takes pictures of my entire body. There’s an ultrasound of my heart. Salade Ni?oise for lunch. A stool sample. A cognitive test in which letters flash on a computer screen at a dizzying pace. And a CT scan of my heart as well, which originally seemed so over-the-top for someone my age that I tried to get out of it.【閱讀全文】

Sarepta sells Exondys 51 PRV to Gilead for $125M

Sarepta has struck a $125 million deal to sell a voucher it got with last year’s controversial FDA approval of its new Duchenne drug to Gilead, which will give the Big Biotech a one-time speedy review pass for an NDA app to the U.S. regulator.

The biotech got the Rare Pediatric Disease Priority Review Voucher as part of its green light for Exondys 51 in certain Duchenne patients in the fall of last year. Analysts had long expected the biotech to sell the valuable voucher.【閱讀全文】

OncoGenex Pharmaceuticals, Inc. Announces Phase 2 Apatorsen Data for Two Clinical Trials

OncoGenex Pharmaceuticals, Inc. (NASDAQ: OGXI) today announced that apatorsen results from two randomized Phase 2 clinical trials were presented at the American Society of Clinical Oncology (ASCO) 2017 Genitourinary Cancers Symposium, held February 16th- 18th in Orlando. Clinical data from trials in bladder and prostate cancers demonstrated apatorsen was well-tolerated and improved patient outcomes when administered in combination with standard-of-care treatments.【閱讀全文】

Buyout buzz swells for the giant Bristol-Myers after Carl Icahn makes an entrance, stage left

Carl Icahn, the aging activist who’s prodded a series of high-profile biopharma companies into the arms of eager buyers, has taken a stake in the highly stressed Bristol-Myers Squibb, building speculation that the troubled giant could be in line for a buyout – as improbable as that may sound to many.

Bristol-Myers started the day by announcing that it added three new directors and struck a $2 billion stock buyback deal in a pact with Jana Partners, another activist which has been spurring Bristol-Myers to take action to get out of the rut it’s found itself in.【閱讀全文】

VBL Therapeutics Reports Full Data for VB-111 Monotherapy in Phase 2 Trial for Recurrent Thyroid Cancer

VBL Therapeutics (NASDAQ:VBLT), announced today full results from its exploratory Phase 2 study of VB-111 (ofranergene obadenovec) in patients with advanced, differentiated thyroid cancer. The data will be presented today by Dror Harats, M.D., CEO of VBL Therapeutics, at the Federation of the Israel Societies for Experimental Biology (FISEB) conference in Eilat, Israel.【閱讀全文】

Pfizer Announces Acceptance of Regulatory Submission for Inotuzumab Ozogamicin by the U.S. Food and Drug Administration

Pfizer Inc. (NYSE:PFE) today announced that a Biologics License Application (BLA) for inotuzumab ozogamicin has been accepted for filing and granted Priority Review by the U.S. Food and Drug Administration (FDA). Inotuzumab ozogamicin is being evaluated for the treatment of adult patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL).【閱讀全文】

Top 10 U.S. patent losses of 2017

Among the many meds that’ll lose patent protection in the U.S. this year are 10 drugs that each contribute in a big way for top drugmakers. Eli Lilly, Pfizer, Takeda, Bristol-Myers Squibb and Gilead are each set to hit the patent cliff this year with some of their respective big sellers.

Together, they brought in more than $10 billion last year in the U.S. and cover a range of indications: multiple sclerosis, HIV, erectile dysfunction and cancer, among others. They’ll be hot targets as generic rivals rush to steal share with cheaper options.【閱讀全文】

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